Bioreactors could be used to simulate the growth conditions of cells and tissues in vivo which have benefits for the proliferation and differentiation of seeding cells and the tissue construction in vitro. Some papers in this issue were introduced and the application of bioreactors in tissue engineering were summarized. It was suggested to use the multidisplinary approach including the biomochanical methods to develop the bioreactors and to investigate the key parameters of the cells growth and tissue construction for the functional tissue engineering.