YANG Jinfeng,GAO Yongjia,ZHANG Chi,CHANG Feiyan,LI Deyu.Hemodynamics Study of Internal Carotid Artery:A Comparison Between Unidirectional and Bidirectional Coupled Multi-Scale Model[J].Journal of medical biomechanics,2019,34(2):166-172
颈内动脉血流动力学研究:多尺度单、双向耦合模型对比
Hemodynamics Study of Internal Carotid Artery:A Comparison Between Unidirectional and Bidirectional Coupled Multi-Scale Model
Received:February 14, 2018  Revised:April 23, 2018
DOI:
Chinese key words:  Willis环  颈内动脉  血流动力学  多尺度模型
English Key words:circle of Willis  internal carotid artery  hemodynamics  multi-scale model
Fund project:国家重点研发计划(2017YFB0702501),国家自然科学基金项目(11672026)
Author NameAffiliation
YANG Jinfeng School of Biological Science and Medical Engineering, Beihang University 
GAO Yongjia School of Biological Science and Medical Engineering, Beihang University 
ZHANG Chi Advanced Innovation Center for Biomedical Engineering, Beihang University 
CHANG Feiyan Radiology Department, China-Japan Friendship Hospital 
LI Deyu Advanced Innovation Center for Biomedical Engineering, Beihang University 
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Chinese abstract:
      目的 比较多尺度单、双向耦合模型所得颈内动脉中血流动力学差异,为后续研究提供模型选择的参考依据。方法 基于1例颈内动脉轻度狭窄患者的核磁图像,构建其Willis环集中参数模型及颈内动脉三维模型,通过单、双向耦合构建两种不同的多尺度模型。结果 随着狭窄程度的增加,两种耦合方式下颈内动脉入口及出口血流量、血压均随之减小,颈内动脉低时间平均剪切力和高振荡因子的分布区域均大体上随着狭窄程度增加而增大。双向耦合在70%狭窄时大脑前动脉血管段剪切力较低、振荡因子较高,后交通动脉出现流向改变,与单向耦合结果差异显著。结论 在狭窄程度较低时,两种耦合方式的结果大体一致,在70%狭窄时存在显著差异。双向耦合的结果更接近生理参数。研究结果可以更好地应用于脑血管病的血流动力学研究。
English abstract:
      Objective To compare the hemodynamic characteristics in internal carotid artery models, which were obtained by multi-scale unidirectional and bidirectional coupling models, so as to provide references for selecting models in further studies. Methods Based on the nuclear magnetic resonance image of one patient with mild stenosis of internal carotid artery, the lumped parameter model of the circle of Willis and the three-dimensional model of internal carotid artery were constructed. Those two different multi-scale models were constructed by unidirectional and bidirectional coupling. Results With the increase of stenosis degree, the inlet and outlet blood pressure and the outlet blood flow of internal carotid artery all decreased under two kinds of coupling method. The distribution of low time average wall shear stress (TAWSS) and high oscillatory shear index (OSI) of the internal carotid artery both increased with the increase of stenosis degree under two kinds of coupling method in general. The anterior cerebral artery segment showed lower shear stress and higher OSI with bidirectional coupling in 70% stenosis, and the blood flow direction of posterior communicating artery was changed, which was significantly different from unidirectional coupling results. Conclusions At a low degree of stenosis, the result of those two kinds of coupling method were consistent in general, but there was a significant difference in 70% stenosis, and the result of bidirectional coupling was closer to physiological parameters. The research findings can be better applied to the hemodynamic study of cerebrovascular diseases.
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