Hemodynamics is closely related with the initiation, development and treatment of neo-cardiovascular diseases. The studies on the hemodynamics in neo-cardiovascular system are the hotspots of biomechanics and biomedical engineering. The research topics, research method, research achievement and its medical application, which are issued in the articles in this special column, were remarked. Emphasis was paid to the review of the research driver, research progress and research tendency of hemodynamics. The application prospect of hemodynamics research on the clinical procedure and healthcare was demonstrated with respect to its multi level application in prevention, diagnosis and treatment.