Objective The cancellous marrow were implanted in the holes of the mandible prosthesis to study whether the cell bone can reach growing stress level under normal human condition. The threshold value of growing stress can combine the prosthesis and mandibular. Method Three types of defection- Central defect, Lateral defect, Hemimandible defect- were simulated in mandibular geometry model, three types of prosthesis were designed accordingly and holes were made in the prosthesis. The cancellous marrow were implanted in those holes and FE software (Ansys8.0) was used to analysis the stress level of cancellous bone. Results Stress level of Cancellous bone in three types of prothesis were studied and the threshold value of growing stress level on cancellous bone was determined. Conclusions The stress of cancellous bone implanted in the prosthesis can reach the bone cell growing level, and this can give guidance in prosthesis design.