Objective To evaluate the safety and therapeutic efficacy of three-dimensional-printed personalized cervical correction pillows for treating cervical spondylotic radiculopathy. Methods A finite element model was established to simulate and analyze the biomechanical changes in cervical spine before and after using the pillow. Additionally, 20 patients with chronic neck pain were included to analyze changes in visual analogue scale (VAS) scores, neck disability index (NDI), pressure pain threshold (PPT), Borden value, cervical lordosis, T1 slope, cervical slope, and thoracic inlet angle before and after using the pillow. Results Finite element analysis indicated that the maximum stress on vertebral bodies increased by 64.35% and the maximum stress on cartilage tissues by 5.09% after using the pillow. The Borden value improved by 45.75%. Clinical studies showed a significant reduction in VAS scores, NDI, and PPT after treatment (P<0.05), while PPT, Borden value, cervical lordosis, T1 slope, and thoracic inlet angle significantly increased (P<0.05). Conclusion The 3D-printed personalized cervical correction pillow is safe and effective in alleviating neck pain and improving cervical curvature. It provides a new and effective non-surgical treatment option for cervical spondylotic radiculopathy, with significant clinical implications.