Objective To study the influence of stent and balloon shape on hemodynamics in tapered vessels with multiple stenosis. Methods The hemodynamic model was established after the implantation of vascular stent in tapered vessel with multiple stenosis. The numerical simulation method was used to study the effect of the combination of different shaped stents and balloons on postoperative hemodynamics. Results When the cylindrical stent was expanded using cylindrical balloon and tapered balloon respectively, compared with cylindrical balloon expansion, the proportion of low-speed blood flow area generated by tapered balloon expansion was reduced by 0.58%, and the proportion of low time-averaged wall shear stress (TAWSS) area was reduced by 3.22%. The use of tapered balloon for expansion could produce less low-speed blood flow and low TAWSS area. When tapered balloon was used to expand the cylindrical stent and tapered stent respectively, compared with expanding tapered stent, the proportion of low-speed blood flow area generated by expanding cylindrical stent decreased by 1.35%, and the proportion of low TAWSS area decreased by 9.73%. Conclusions The hemodynamic environment of tapered vessel with multiple stenosis was influenced by the shape of stent and balloon. The use of tapered balloon to expand the cylindrical stent in tapered vessels with multiple stenosis can achieve favorable hemodynamic environment and reduce the risk of ISR occurence. This study can provide a scientific basis for the rational formulation of clinical intervention scheme.