Objective To develop a quantitative methodology for assessing the aortic media damage induced by stent-grafted by integrating mechanical experimentation, continuous damage theory and finite element analysis. The investigation focuses on the influence of various oversizing ratios on the integrity of the aortic media.Methods Utilizing uniaxial tensile testing datum from aortic walls of patients with TEVAR, the material parameters of aortic wall"s constitutive equation, inclusive of damage parameters, were meticulously determined. A finite element model was constructed to simulate the deployment process of stent-grafted. Damage factor was delineated to scrutinize the stress distribution and the resultant damage within aortic media under a spectrum of oversizing ratios of stent-grafted. Result The damage factor exhibited a distribution congruent with that of the Von Mises stress, with both peaking at the convex aspect near the aortic arch. Additionally, stress concentration was observed in the distal anchoring re