Biomechanical Response of the Utricular Macula to Linear Acceleration Based on a Bionic Physical Model
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Abstract:
Objective This study aims to construct a transparent and visualized bionic model of human utricle and explore the biomechanical response of linear acceleration of utricle. Methods Using 3D printing technology and PVA-gelatin composite hydrogel fabrication method, a visual utricle physical model with a ratio of 10:1 to the human body was successfully prepared. The biomechanical response of the utricle macula was investigated by varying acceleration and direction stimulation experiments. Results Under 1-5 Hz sinusoidal reciprocating linear excitation, the response amplitude of the bionic macula increased from 4.11 μm to 48.82 μm. The response amplitude of the biomimetic macula increased linearly with acceleration. In addition, the macula showed deformation differences in response to acceleration in a specific direction. Conclusion The bionic utricle model can accurately simulate the working mechanism of human utricle, which is expected to provide a new way for the pathological study of vestibular dysfunction and expand a new direction for the application of bionic technology in the field of biomedical engineering.
