Objective To compare the stability of different Kirschner wire configurations for treating SH-2 type epiphyseal injury and damage to the epiphyseal plate in children. Methods The CT scanning data of a healthy femur from an eight-year-old child were collected; the image data were imported into Mimics 21.0 to establish a rough femoral and epiphyseal model, which was then imported into Geomagic 2013 to construct a surface model. The surface model was assembled in SolidWorks 2018 with three configurations (dispersed, double-crossed, and single-crossed K-wires) and then imported into ANSYS Workbench 2019. Various motion modes in reality were simulated through different mechanical loadings on the assembly. The maximum displacement of the fracture fragment, von Mises stress distribution, and maximum stress on the K-wire, epiphyseal plate, and fracture fragment were analyzed. Results The maximum displacements of the dispersed, double-crossed, and single-crossed K-wire groups occurred during abduction (2.39 mm), adduction (2.12 mm), and abduction (2.21 mm), and the maximum stress on the epiphyseal plate occurred during abduction (1.22 MPa), anterior flexion (0.20 MPa), and posterior extension (0.29 MPa), respectively. Conclusions The stability of the double-crossed K-wire configuration was superior to that of the dispersed and single-crossed K-wire configurations, with minimal damage to the epiphysis.