Objective To improve the efficiency and quality of end-to-end anastomosis, we designed a novel degradable vascular anastomosis device and explored the relationship between the pressure distance and the biomechanical properties of anastomotic stoma. Methods The vascular anastomosis device designed in this study contains three parts: the right and left inner ring, and the outer ring, which all made by extruded high-purity magnesium. The finite element model of end-to-end vascular anastomosis under different pressure distances (0.4, 0.5, 0.6, 0.7 and 0.8 mm) was established to study the stress distribution and its change rules of the anastomosis end face. In vitro experiments were conducted to study the changes of operate time, anastomosis strength and microstructure observation at different pressure distances. Results When the pressure distance was 0.6 mm, the anastomosis tensile force and burst pressure could reach 11.79±0.64 N and 39.32±2.99 kPa, respectively, which meet the clinical requirement for the strength of vascular anastomosis, and with minimal mechanical damage. Conclusion The device designed in this study can used for vascular anastomosis by adjusting the pressure distance which can improve the efficiency of operate, reduce the mechanical damage of tissue and further improve the quality of anastomosis. The research results provide references for the design of degradable vascular anastomosis devices.