Objective To analyze the adaptability of different materials based on a defined coronary stent design, and to establish an evaluation method for stent design-material selection. Methods Using finite element numerical simulation method, the expansion performance of the stent in blood vessel were analyzed, and the safety and usability of the stent design and materials were investigated for five potential applicable materials. For non-degradable materials, the focus was on the fatigue resistance performance after long-term implantation; while for degradable materials, the changes of support force during degradation were analyzed to clarify the rules of support force provided by the stent. Results For the specific coronary stent design, the simulation showed that for 316L stainless steel and L605 cobalt-chromium alloy stents, the radial recoils were 26% and 19% , the axial foreshortening were 0. 22% and 0. 28% , the maximum equivalent stresses were 551. 2 MPa and 829. 1 MPa, and the fatigue dynamic safety factors were 1. 36 and 1. 67, respectively. For degradable materials AZ31 magnesium alloy, iron and poly (L-lactic acid) (PLLA), the simulated damage time of the stents based on this design was 30h and 180 d, 270 d respectively. Conclusions Based on stent design in this study, the L605 cobalt-chromium alloy exhibited the best expansion performance and fatigue resistance to match the clinical requirements. Compared with the rapid degradation damage of AZ31, the mechanical properties of iron stent and PLLA stent were close but still needed structural optimization. The finite element numerical simulation, especially analysis on expansion performance and fatigue resistance, can effectively simulate mechanical behavior of the stent and provide references for the selections of stent materials and the design optimization.