Hydrogel is an important biomaterial and a hot research topic in biomedical area. However, the micro environment and regulation mechanism of cells and tissue in human body are very complex, there are still some unsolved questions during the application of hydrogel in regeneration and repair area. Along with the development of biomechanics, more and more researchers have found that the biomechanical properties of hydrogel are also one of the key factors in regulating cell function and affecting tissue regeneration and repair, in addition to the material and biological properties. Therefore, we summarized the biomechanical research progress of hydrogel materials, and prospects the future research.