Objective To optimize the connection between the three-dimensional ( 3D) printed self-positioning titanium mesh main body and the positioning wings at both ends, including thickness, width and connection configuration of the positioning wings at the connection, and to analyze and optimize structural performance of the simulation model before and after the improvement, ultimately obtain the optimal design of a novel self-positioning titanium mesh. Methods A self-positioning titanium mesh simulation model was built in software SolidWorks to optimize and improve dimension parameters. Then, the multi-objective optimization design for thickness and width of the connection was conducted using the simulation software ANSYS Workbench. A discontinuous connection configuration was designed at the connection to obtain an optimized self-positioning titanium mesh. Results When the 40 N load was applied to outer surface of the novel self-positioning titanium mesh alveolar crest, the maximum strain at the connection did not exceed fracture strain of the titanium mesh, and the stress and deformation were within an acceptable range. When the 10 N bending force at 45° angle was applied to free end of the positioning wing on one side, the maximum strain at the connection exceeded the fracture strain of the titanium mesh, and the crack propagation path was concentrated at the connecting line. The experimental results of the virtual model were basically consistent with the results of mechanical performance verification test. Conclusions By optimizing the dimension and configuration of the individualized self-positioning titanium mesh connectome, the connectome does not break or shift significantly when the individualized titanium mesh is placed and pressed during surgery. After surgery, simply bending free end of the positioning wing can achieve a neat fracture and separation of the connector along the connecting line, with a smooth and flat cross-section. This study has achieved ideal clinical results by optimizing the dimension and configuration of the individualized selfpositioning titanium mesh connectome.