The ear, nose, and throat (ENT) organs are directly in contact with the external environment and help humans perceive information from the outside world. The implementation of the functions of these organs and the development of the related diseases are closely related to mechanical factors. In this review, combined with the latest literature in the field of otolaryngology in 2022, the progress of acoustic conduction in the ear was summarized, including the processes of air conduction and bone conduction, the balance function of the vestibular system, the treatment of obstructive sleep apnea-hypopnea syndrome (OSAHS), the relationship between nasal diseases and structure, and the impact of nasal diseases on adjacent organs. The future research direction in the field of biomechanics of otolaryngology was also discussed.