Abstract:Objective: To compare the corneal biomechanical parameters identified from the data of uniaxial test with fast vs slow loading on rabbit corneal strips. Methods: The stress-strain data and stress relaxation data were obtained from uniaxial tensile tests of the corneal strips from 15 healthy adult rabbits at loading rates of 0.1 mm/s and 0.02 mm/s, respectively. A visco-hyperelastic model was applied to analyze the loading and unloading data from the fast stretch tests, where the model parameter set was denoted by Gvh. The first-order Ogden model and second-order Prony series model were used to fit stress-strain data and stress relaxation data from the slow tensile tests, respectively, in which the model parameter set was denoted by GVH. Correlation analysis was used to compare the correlation of parameters between GVH and GOP. Results: All the goodness-of-fits to the 3 data sets were greater than 0.95. There were significant differences in 5 of the 6 parameters between GVH and GOP (P < 0.05), and the Ogden model parameters was positively correlated between the two groups. Conclusions: There are differences in corneal biomechanical parameters identified based on fast and slow loaded uniaxial tensile data. Further research is needed to understand and explain these differences and how to apply them.