Objective In this study, a personalized design, optimization and manufacturing method of 3D printing implant for repairing large area of maxillary defect was proposed. Method Based on the patient's CBCT and oral scan data information to design the implant; Using finite element analysis method to iteratively optimize the structure and material selection of the implant. Simulate the force of the implant in the oral cavity, obtain the magnitude, conduction direction and distribution of the stress on the implant, and optimize the structure of the implant accordingly. Finally, compare the maximum equivalent stress, the maximum equivalent stress of the jaw bone and the total displacement of the titanium screws under the three different materials of titanium alloy, tantalum metal, and Peek of the same configuration, and determine the printing material of the implant. Use 3D printing technology to print the implant, and the clinical surgery to facial remodeling and occlusal reconstruction. Result Through the iterative optimization of the structure, the best configuration of the implant is obtained. Compare the maximum equivalent stress, the maximum equivalent stress of the jaw bone and the total displacement of the titanium screws of three different materials under the same configuration, the titanium alloy material was selected. 3D printed implants were used in the clinic to complete the occlusal reconstruction. Conclusion The method described in this study has clinical feasibility and is suitable for different types of maxillary defect cases. It not only restores the patient's maxillofacial appearance, but also meets the clinical needs of occlusal reconstruction after maxillofacial defect repair, which proves the effectiveness and practicability of this method.