Abstract: Objective To explore the effects of different contact areas on the biomechanical response parameters of rabbit skull fractures under quasi-static compression conditions. Methods The rabbits were divided into two groups: scalp preservation and scalp removal. Each group was divided into three groups of 3mm, 6mm, and 9mm according to the contact diameter of the wounded material. There were 9 rabbits in each group, totaling 54 rabbits. All rabbits were put to death by over anesthesia and made into a skull compression model. An electronic universal material testing machine was used to perform quasi-static compression of rabbit skulls to fractures, and biomechanical response parameters such as ultimate load, deformation under ultimate load and compression strength of rabbit skulls in each group were detected. Results The difference in ultimate load, deformation under ultimate load and compressive strength of rabbit skulls in the scalp preservation group and the scalp removal group under different contact areas was statistically significant (F values were 62.78, 4.06, 102.93, P<0.05; 55.62, 12.68 , 208.67, P<0.05). The ultimate load is positively correlated with the contact area (r=0.883, P<0.05), and the compression strength is negatively correlated with the contact area (r=-0.903, P<0.05). There is no correlation between the deformation under ultimate load and the change of the contact area (P>0.05).The difference between the scalp-preserving and scalp- removing groups was statistically significant (P<0.05) in the group with a contact surface diameter of 3 mm, and there was no statistical significance in the other groups (P>0.05). Conclusions The contact area is positively correlated with the ultimate load of rabbit skull fracture, negatively correlated with the compression strength, has no correlation with the deformation under ultimate load and has nothing to do with whether the scalp is removed.