Objective A mechanical model with the number of laser treatment as the independent variable in the treatment process of rabbit ear hypertrophic scar (HPS) was established by combining experimental research and numerical simulation to evaluate the clinical efficacy of HPS. Methods Firstly, the HPS model of rabbit ear was established by CO2 laser, and then the HPS was treated for continuous three times by pulsed dye laser (PDL) combined with CO2 lattice laser. After each treatment, the uniaxial compression mechanical properties of HPS were tested to fit Ogden hyperelastic model to obtain the mechanical parameters of HPS during the treatment. The functional relationship between the mechanical parameters of HPS and times of laser treatment was established by LM optimization algorithm. Results The mechanical parameters of HPS increased with the increase of laser treatment times, and gradually tend to a constant, that is, the mechanical parameters of normal skin. With the increase of laser treatment times, the growth ratio of HPS mechanical parameters gradually decreased. The initial growth ratio was 60% and decreased to 4.09% after three times of treatment. Conclusions The initial therapeutic effect of laser therapy is the most obvious, and with the relief of symptoms, the effect of single laser therapy is no longer significant.