Objective The effect of irrigation mechanical stimulation on the degradation of scaffold was studied by numerical simulation to predict its degradation degree. Methods Based on the perfusion experimental data, the fluid-solid coupling model was established by Comsol. The finite element model of scaffold was established by Abaqus. Based on the models, the degradation performance of scaffold was obtained. Results (1) The fluid-solid coupling simulation shows that the initial pressure at the speed of 15.79mL /min is two-fold at 7.89mL /min. Along the thickness of scaffold from the surface to the bottom, the pressure values between the two velocity are gradually close to each other. (2) The degradation of scaffold structure can be simulated dynamically by combining the degradation constitutive model and finite element model. The degradation data obtained are consistent with the experimental data, and the β value can reach 0.643 on the 56th day. Compared with the experimental data, the simulation accuracy is higher than 98%. Conclusion (1) Fluid-solid coupling simulation shows that the larger the perfusion velocity is, the greater the pressure on the scaffold will be. Under the same perfusion velocity, the maximum force occurs on the surface of scaffold. (2) The degradation law of scaffold can be predicted by applying the degradation constitutive model and finite element model.