Exosomes are extracellular vesicles secreted by cells with a variety of molecular components, which can play the role of substance transport and signal communication between cells through autocrine and paracrine. Exosomes exist widely in vivo and participate in many physiological and pathological processes, including force-related periodontal inflammation. There are stress receptor cells in periodontium, which can sense the force loading on tooth. An appropriate amount of mechanical loading can maintain the health of periodontium, while excessive mechanical loading may cause the destruction and absorption of periodontium, leading to the periodontal inflammation. This article reviews the role of exosomes in force-related inflammation response, especially in periodontal inflammation response.