Abstract: Objective To investigate the distribution of streaming potential generated by interstitial fluid flow in articular cartilage and to obtain the electrical characteristics of articular cartilage. Methods In this paper, the governing equation of fluid and electrostatic theory were combined to establish a two-dimensional microelement model of cartilage, and the steady flow potential generated in the microelement under certain pressure was calculated by finite element method. Results The streaming potential in the micropore model of articular cartilage with the length of 5μm was about 38.4μV. The effect of external pressure and Zeta potential on the streaming potential of articular cartilage model was significant and showed a linear increase relationship.The streaming potential decreased with the increase of ion concentration, but the high and low concentration had different effects on the streaming potential of cartilage. When the ion number concentration was low, the streaming potential was more dependent on the ion number concentration.When the ion number concentration is high, the effect of ion number concentration on the streaming potential is very small. Conclusion The results of this study provide important theoretical basis for the differentiation and proliferation of chondrocytes, the prevention and treatment of important theoretical basis for the differentiation and proliferation of chondrocytes, the prevention and treatment of important theoretical basis for the differentiation and proliferation of chondrocytes, the prevention and treatment of articular cartilage diseases, the development of tissue-engineered cartilage and the repair of articular cartilage injury by means of electric current, electric field and electromagnetic field stimulation.