Advanced Glycation end-products (AGEs) are the products of non-enzymatic reactions between free amino groups of macromolecules and reducing sugars. The accumulation of AGEs in bone tissue changes the activity and function of bone cells by binding to their surface receptors, causing abnormalities in the process of bone remodeling. Accumulation of AGEs can also change the original structure and mineral deposition of bone collagen to affect the micro-mechanical properties of bone tissue, and further reduce bone strength and toughness and increase the bone fracture risk, leading to bone diseases and harmful to human health. This paper summarized the causes of AGEs and their detection methods, and reviewed the previous studies on the effects of AGEs accumulation on bone biomechanics in micro and macro levels, hoping to provide some clues for the early diagnosis and treatment of bone diseases clinically.