Objective Open-type stent retrievers are effective devices for the acute ischemic stroke (AIS). This article simulated the thrombus removal process of the open-type stent retrievers and the results can be used as the design and clinical application of the open-type stent retrievers. Methods Established finite element models of different supporting cells (3, 4, 5) open-type stent retrievers(K3,K4,K5), crimping tools, simulated vessels and simulated thrombus (three types) .Displacement load was applied on the radial direction of the crimping tool until the stents was crimped to 0.5mm, the maximum principal strain(MPS) peak and the radial force of the stents were analyzed. Restored the displacement of the crimping tool, stents self-expanded and contacted with blood vessel, analyzed the MPS of the stents and the Von Mises stress (VMS) of the blood vessel. Applied axial displacement on the proximal end of the stent retrievers, analyzed the blood vessel VMS and withdrawal force (the clot-capturing ability). Results The MPS peaks of the three stent retrievers during the crimping process were 6.94%, 8.30%, and 5.48%, which were all less than the fracture limit of 12%.When the outer diameter of the stents was 3mm (equal to the inner diameter of the blood vessel), the number K4 stent had the largest radial force. The results of self-expanding release process showed that the larger the number of support cells, the greater the VMS of the blood vessel. And the results were all less than the limit stress 1.44 MPa. During the migration and removal stage, it was found that the VMS of the blood vessel were generally small and concentrated on the thrombus. The withdrawal force of the stents reached the maximum value at first, then gradually decreased. The peak withdrawal force of the K4 stent was biggest of all. Conclusions Although the MPS and VMSthe three open-type stent retrievers were within the safe range, the K4 stent had the advantages on radial force and withdrawal force with the three types of thrombus. The results of this study can provide an analysis method and ideas for optimizing the open-type stent retrievers to avoid clinical complications such as vascular injury and improve the safety and effectiveness of the stent retrievers.