The modeling study of influence of cell-ECM adhesion on migration of tumor cells regulated by ECM stiffness
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1.taiyuan university of technology;2.North University of China

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The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    Abstract:

    Abstract: Objective To study the influence of cell-ECM adhesion on migration of tumor cells regulated by ECM stiffness. Method The cellular Potts model (CPM) was established to simulate the procession of tumor cells and the cellular immune feedback system, the effects of cell mechanical behavior on cell-extracellular matrix adhesion were observed, and the migration of tumor cells under different extracellular matrix was analyzed. Results Under the different cell-matrix adhesion, tumor cells could migrate at different speeds. At the same time, the change of extracellular matrix stiffness regulates the adhesion force between cells and matrix. With the increase of extracellular matrix stiffness, the concentration of adhesion molecules raised, which reduced the migration rate of tumor cells. Conclusions The results show that the migration and distribution patterns of cells are closely related to the adhesion and stiffness of extracellular matrix. Increasing the stiffness of extracellular matrix can effectively control the migration rate of tumor cells. These findings may further reveal the dynamic changes of extracellular matrix, the size of adhesion and the mechanical manifestation of tumor cells migration.

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History
  • Received:July 14,2020
  • Revised:September 05,2020
  • Adopted:September 10,2020
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