Objective: The 3D printed personalized polyether ether ketone (PEEK) condyle prosthesis was subjected to finite element analysis and compressive performance testing, to analyze the stress distribution characteristics and mechanical properties of the prosthesis, and to evaluate the clinical value and prospect of the prosthesis. Methods: The finite element models of PEEK condyle prosthesis, mandible and fixation screw were established through softwares such as CBCT, Mimics, Geomagic Studio, sholiworks and ANSYS Workbench. Load the maximum mastication force, record the maximum stress of the condyle prosthesis and screw, and the stress and strain of the mandible. In order to simulate the actual clinical situation, a special fixture was designed to test the compression performance of the condyle prosthesis prepared by the two methods of FDM and SLS at a rate of 1 mm / min. Results: Finite element analysis found that the peak stress of the PEEK condyle prosthesis was located at the back of the condyle neck, which was 10.733MPa; the peak stress of the 5 fixing screws appeared on the 2 # and 5 # screws near the trailing edge of the mandibular ascending branch. The peak stress was 9.7075 MPa; the peak stress of both the prosthesis and the screw is less than its yield strength. The compression experiment found that the maximum pressure that the condyle prosthesis prepared by FDM and SLS can bear was 3814.7 ± 442.6 N and 1193.970 ± 260.350N respectively. Compared with the SLS preparation, the FDM prepared prosthesis not only had higher compression strength but also better toughness. Conclusion: 3D printed personalized polyetheretherketone condyle prosthesis shows uniform stress distribution and good mechanical and mechanical properties, which can provide a theoretical basis for PEEK as a reconstruction material for repairing temporomandibular joint.