The role of microRNA in force-related periodontal inflammatory response and tissue remodeling
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1. Department of Prosthodontics,Shanghai Ninth People’s Hospital,College of Stomatology, Shanghai Jiao Tong University School of Medicine;2. National Clinical Research Center for Oral Diseases;3. Shanghai Key Laboratory of Stomatology &4.Shanghai Research Institute of Stomatology

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    Abstract:

    miRNA is a kind of non-coding single-stranded RNA, which can regulate the expression of genetic information by inhibiting mRNA translation of the target gene and participate in the occurrence and development of a variety of biological processes in vivo. miRNAs also take part in inflammatory diseases and tissue remodeling induced by mechanical forces. Mechanosensitive cells in periodontal tissue can lead to pathological/physiological changes such as periodontal inflammatory response and periodontal remodeling. miRNAs might have played important roles in the occurrence and development of force-related periodontal inflammatory diseases and tissue remodeling, by inhibiting the translation of specific genes in these cells. This article reviews the roles of miRNAs in force-related inflammatory response and tissue remodeling, especially in periodontal inflammatory response and tissue remodeling.

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History
  • Received:March 06,2020
  • Revised:May 05,2020
  • Adopted:May 06,2020
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