Objective: to establish a finite element model of tibial and fibular anterior ligament injury after ankle fracture fixation, and to compare the stress and deformation of the model with bolt fixation, so as to provide theoretical basis for clinical diagnosis and treatment. Methods: a CT image of ankle joint of a normal young man was selected to establish a finite element model of anterior tibiofibular joint injury after ankle fracture fixation. The injury model was fixed with anchor screw as the experimental group and screw as the control group. Through the finite element analysis and calculation, observe the maximum stress distribution and the maximum deformation of the two models under various load conditions. Results: under the vertical load, the deformation of the experimental group was 6.8% higher than that of the control group, 22.6% under the external rotation load, and 5.1% lower under the internal rotation load; under the same level of load, the maximum stress peak of the model in the control group and the experimental group was almost the same; the maximum stress in the experimental group, because of the role of anchor fixation, the maximum stress peak was fixed by the distal tibial fracture Screw bearing. In the control group, steel plate and screws were used for rigid fixation; the maximum stress values on the anchor were all distributed on the screws, and the suture was mainly used for fixation. Conclusion: the lower tibiofibular screw and anchor screw fixation can effectively treat the tibiofibular instability caused by ankle fracture fixation. The anchor screw fixation can disperse the stress on the steel plate, and has a greater ankle deformation ability while fixing the lower tibiofibular, and avoid the risk of nail breakage. It has a promising clinical application prospect.