Purpose: Muscle isometric resistance training is an integral part of muscle strength training. Therefore, the research explores the characteristics of nerve adaptation of Maximum Voluntary Contraction (MVC ) resistance training at different joint angles, in order to provide a reference for muscle strength training, rehabilitation training, and revealing neural adaptation mechanism of muscle resistance training.Methods: Thirty healthy male college students were recruited and randomly divided into 3 groups. Each group had an elbow joint angle of 45°, 90°, and 135° MVC isometric contraction resistance training (the forearm was extended at the elbow joint defined as 0°). The subjects were trained 3 times a week, and each training completed 3 MVC resistance training for 5s, and trained for 6 weeks. Results: The RMS normalization values of the biceps muscles surface electromyography (SEMG)before and after training at 45°elbow joint angle were 0.572±0.064, 0.605±0.051; the 90° angle was 0.594±0.061, 0.664±0.061; the 135° angle was 0.580±0.067, 0.651±0.053; there were significant differences after training among three different angles. However, there is no significant difference in MF normalized values of each angle after training.Conclusion: According to the RMS specific change ofSEMG, the biceps brachii is in the middle and large elbow joint angle isometric resistance training produces better nerve adaptation effect. It is suggested that for patients who cannot complete dynamic rehabilitation training, the use of middle and large joint angle isometric strength training will obtain better neural adaptation training effects.The Median frequency (MF) of SEMG signal does not have Angle specific change.