Hemodynamic Research on Pulmonary Arterial Hypertension Related to Congenital Heart Disease
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1.Shanghai children'2.'3.s Medical Center affiliated to Shanghai Joao Tong University School of Medical

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The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    Abstract:

    Aim: Hemodynamic disorder of the pulmonary artery (PA) is the main cause of pulmonary arterial hypertension related to congenital heart disease (PAH-CHD). Studying the hemodynamic characteristics of the pulmonary vascular is helpful to understand the biomechanical factors in the occurrence and development of PAH-CHD, which will greatly benefit the control, improvement and treatment of PAH-CHD. Methods: Five PAH-CHD patients and five matched controls were enrolled. Subject-specific three-dimensional PA models were reconstructed based on computed tomography. Computational fluid dynamics was performed to compare the hemodynamic difference of flow patterns, wall shear stress (WSS) and normalized energy loss (E ?) in the two groups. Results: Hemodynamic analysis showed that the velocity and WSS were higher in the PA branches of PAH-CHD patients, in whom WSS was lower in the main PA. The E ? significantly increased in PAH-CHD patients and positively correlated with normalized PA diameter and inflow. Conclusion: The increased velocity and WSS in the PA branches, decreased WSS in the main PA, and increased E ? may be the potential biomechanical factors in the development of PAH-CHD.

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History
  • Received:August 27,2019
  • Revised:November 30,2019
  • Adopted:December 03,2019
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  • Published: