Abstract: Objective To analyze the hemodynamic parameters of Anomalous origin of the Right Coronary Artery from the Left Coronary artery sinus (ARCA) based on computational fluid dynamics(CFD), so as to make a evaluation of the disease. Methods A normal right coronary artery and an ARCA were selected. Two models were reconstructed in Mimics software and imported into ANSYS CFX software to simulate the hemodynamics. The hemodynamics of two different models were compared. Results ARCA has a smaller volume flow (9.35×10-6m3/s), which may lead to insufficient blood supply downstream of the right coronary artery; The pressure at the corner of the abnormal right coronary artery (13784.96Pa) is lower than normal right coronary artery (14913.82Pa); wall shear stress (WSS) of ARCA (12.83Pa) more than normal right coronary artery (9.74Pa); The total deformation of abnormal right coronary artery is large. Conclusions The entrance velocity and pressure of ARCA are lower than those of the normal right coronary artery, which may lead to ischemic symptoms. It is of theoretical significance for the effective evaluation of ischemia and other diseases in the future.