The Correlation between Mechanical Properties and Hemostatic Ability of Injectable Sealing Hydrogels
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Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences

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    Abstract:

    Abstract: Objective The aim of this study was to investigate the correlation between the mechanical properties and hemostatic ability of the sealing hydrogels. Method Taking hyaluronic acid/gelatin hydrogels as the examples, the gelation time, elastic modulus, viscous modulus, bursting strength and hemostatic ability of the hydrogels were measured to investigate the correlation between mechanical properties and hemostatic ability of sealing hydrogels. Compared with medical hemostatic agent, fibrin glue, the gelation time and mechanical parameters were proposed to judge the feasibility of sealing hydrogels to be used for hemostasis in clinic. Results Hydrogels with a long gelation time, low elastic modulus, low viscous modulus and small bursting strength were merely suitable for hemostasis in minor bleeding. The hydrogels with a short gelation time, high elastic modulus, high viscous modulus and large bursting strength could effectively reduce the blood loss in the case of massive bleeding. Conclusions The hemostatic ability of a hydrogel is correlated to its gelation time, elastic modulus, viscous modulus and bursting strength. To achieve hemostasis as effective as fibrin glue, a sealing hydrogel should gel less than 120 s, its elastic modulus and viscous modulus should exceed 600 Pa and 120 Pa, and its burst strength should not be less than 10.7 kPa, preferably larger than 16.0 kPa, for the tissue model with the damage diameter in 2 mm.

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History
  • Received:May 06,2019
  • Revised:August 25,2019
  • Adopted:September 11,2019
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