Objective As a parameter for functional assessment of coronary artery stenosis FFR has been used in clinic. It has also been suggested to be used in the assessment of carotid artery stenosis. This study explored the feasibility of applying FFR into the assessment of carotid stenosis. The effects of elastic modulus of vessel wall on hemodynamic parameters and FFR of the standard carotid artery stenosis model were also analyzed. Methods Standard models of carotid bifurcation and stenosis models with different stenosis rates were established by computer-aided design software. Assuming that the vessel wall was linear elastic material and the blood was incompressible Newtonian fluid, the fluid-structure coupling simulation of blood flow in carotid artery stenosis model under the pulsating flow was carried out by finite element analysis, and the relevant hemodynamic parameters were obtained, and the corresponding FFR was calculated. Results When the modulus of elasticity is fixed, the FFR of the narrow part of the model decreases gradually with the increase of the stenosis rate, and the relative difference between the FFR of the elastic wall and the rigid wall increases with the increase of the stenosis rate; when the stenosis rate is fixed at 70%, the FFR decreases gradually with the increase of elastic modulus. Conclusion The effect of vascular wall elasticity should be considered during the modelling; The greater the stenosis rate, the greater the influence of elastic modulus of vessel wall on FFR.