Bone is a dynamic organ, and the morphology, structure and function of bone can vary with the size, direction and form of mechanical stimulation. Appropriate mechanical stimulation is the key to maintain the dynamic balance of bone formation and bone resorption. However, with aging, the senescence of bone tissues causes a series of changes, including bone microenvironment, osteocyte morphology, signaling pathways in the osteocyte, etc., which weakens its mechanical response ability and then leads to osteoporosis and other diseases. Therefore, it is of great significance to study how aging affects the mechanical response of osteocyte. This review mainly discusses the influence of aging on mechanical response of the osteocyte.