Objective To observe and compare the effects of intraocular pressure (IOP) drop on using two kinds of aqueous drainage device implantation. Methods Forty healthy New Zealand white rabbits were chosen for the experiments. According to different implant devices, they were divided into NADI (new aqueous drainage implant) group and Ahmed group respectively, with 20 rabbits in each. Results Neither group appeared shallow anterior chamber after operation. At 8th week after operation, the postoperative IOP of NADI group and Ahmed group was decreased by 19.4% and 15.7%, respectively, as compared to the preoperative IOP. Statistical comparison showed that there were significant differences in IOP between two groups within 8 weeks (P＜0.05), and the IOP of NADI group was decreased more significantly than that of Ahmed group. Conclusions The IOP in NADI group was reduced more than that in Ahmed group, and such IOP drop was maintained for a longer period in NADI group, which means that NADI has an obvious IOP drop effect and good prospect in clinical application.