Recently, a novel painless microneedle technology has been developed for transdermal drug delivery, which is believed to be widely applied in clinical therapies. In this review, the development history and current situation of the microneedle technology were first introduced with analysis on existing problems of artificial microneedles. Then, the present researches on biomicroneedles were introduced with discussion on the differences between the artificial micorneedles and biomicroneedles. Due to the limitation of present manufacturing technology, artificial microneedles can not realize such wonderful micro/nanostructures as biomicroneedles and an optimal design as biomicroneedle materials. Moreover, there are differences between the biomicroneedls and artificial microneedles in their penetrating manners. Artificial microneedles can not realize the active control during the penetrating process to reduce the penetrating force. To be as perfect as biomicroneedles, there still exist many problems for artificial microneedles to solve.