Objective To establish patient-specific hexahedral finite element mesh model for the maxillofacial surgery. Methods A standard and common hexahedral finite element mesh model for the face soft tissue was first built by semi-automatic procedure, and the an individual facial hexahedral mesh was then generated by an example learning method based on volumetric mapping. Results It was convenient to generate a high quality patient-specific hexahedral mesh with geometric shape feature and mesh element quality preserved as much as possible with this method. Conclusions The new hexahedral mesh modeling method can provide high quality hexahedral mesh input for biomechanics analysis with good application prospect in many fields such as oral and maxillofacial surgery.