Objective By biomechanical research on maxillary canine with invisible orthodontic appliances, analyze the features of the orthodontic forces and effect of invisible appliances. Method A three-dimensional FE model of canine with the invisible appliance was set up, which includes alveolar bone, periodontal membrane and pulp. Aiming at one kind of tooth’s monstrosity, several simulated cases were designed and analyzed numerically. The forces and moments from the invisible appliance were analyzed. The force and stress distributions applied with the invisible appliance were obtained. And the comparative study was made between the invisible appliance and the traditional fixed aligner. Result Applied with both the invisible appliance and the traditional fixed aligner, the maximal stress on tissues around the maxillary canine showed greatly close, and changing tendency of stresses are very similar. Conclusion Good clinical effect can be gained with the properly designed invisible appliance.