Objective To study the change of hemorrheological index during the steroid-induced necrosis of the femoral head. Methods 20 rabbits were randomly divided into 2 groups. In group A, 10 rabbits were given 40μg?kg^(-1) of LPS intravenously 2 times at an interval of 24 hours, and immediately injected intravenously with 20mg?kg^(-1) of prednisoloni acetates once time. In group B, 10 rabbits were used as control. At the 24th, 3rd, 7th, 14th, 21st day after the injection, hemorrheological index, blood-lipid levels and the blood platelet levels were measured, and then after the last measure the rabbit's femoral head and liver were undertaken light microscopic examination. Results The 24th hour after the injection of group A, hemorrheological index and blood-lipid levels increased (P<0.01), the blood platelet levels decreased (P<0.01). At the 3, 7, 14 and 21 day, abnormal indexes lasted during the whole observation. Histologically, the 21st day after the injection, In group A the degeneration and necrosis of the hepatocytes and osteocytes were found. In group B, the hepatocytes and osteocytes were normal as usual. Conclusion Abnormality in hemorrheological index might potentiate the prethrombotic status and induce the thrombus formation in steroid-induced necrosis of the femoral head.