Objective To study the stress of human femur under the bending moment and compressive load with considering accident twist or tumble happens to the human body in walk. Methods Adopted the Finite Element Method analysis software ANSYS. Based the trim size of human femur, develop plane model using plate42 cell. Excursion the load of node j to outside δ 0 mm、5 mm、10 mm、15mm passed by femur head, simulate the stress distributing of the femur head under the bending moment. Results Obtained the distortion deformation、stress nephogram、section stress of femur neck and upside of femoral shaft of the femur under the bending moment and compressive load. Conclusion There’s a large stress concentration at femur neck. The large tension stress is concentrated at the outside stress nephogram of femur neck, while the inside of it has large compressive stress. The outside of femoral shaft has large tension stress in perpendicular orientation, while the inside of it has large compressive stress. With the increase of bending moment, the stress of femur increases evidently.