Objective The effect of injection strategy on drug transport in 2D solid tumor were investigated to determine the suitable injecting method. Methods By using the tumor capillary network based on numerical angiogenesis, drug transport in a two-dimensional solid tumor was studied. The volume under the surface (VUS) of drug concentration when higher than minimum effective concentration (MEC) in tumor during 24 hours was choosed to evaluate the treatment of drug. Various drug injection methods were investigated and compared. Results When MEC is relatively low, there is not significant difference for various drug injection methods. Injecting drug in a short period would be more effective if MEC is relatively high. Conclusion The drug injection strategies for solid tumor therapy should be designed and optimized according to the characters of tumor cells and the effect of various typical drug injection-methods.