Objective To measure the biomechanics of memory alloy wire netting ball and investigate the application ofthe kyphoplasty instrument for osteoporosis vertebra compression fracture. Methods Super elasticity netting ball wasmade of memory alloy nickel-titanium wire with different diameter. The loading and unloading strength were measuredafter making the netting ball bipolar and two sides fixed. An instrument was made to extend and compress netting ball toinvestigate its kyphoplasty effect for osteoporosis vertebral compression fracture. Results The maximal loadingstrength increased along with the diameter of memory alloy wire and it could be 162.39 N when using 0.38 mm diameterwire to make netting ball. The kyphoplasty instrument of netting ball could work through pedicle of vertebral arch.Conclusion The kyphoplasty instrument of memory alloy wire netting ball could be a new method to treat osteoporosisvertebra compression fracture, and the clinical effect still need further study.