Speckle metrology, which was created in 60's, is one of photomechanics in experimental mechanics. This method has hitherto been developed and applied widely in many engineering fields, including biomedical engineering. The author summarily explained the principle and characteristic of speckle metrology as well as the application of main speckle metrologies used in biomedical field, such as speckle photography、speckle interferometry、electronic speckle pattern interferometry、digital speckle correlation methodand bio-speckle method.i it's development in the future has also been introduced.