Objective To investigate the effects of pharyngeal respiratory pressure on the mechanical properties of soft palate in obstructive sleep apnea hypornea syndrome (OSAHS). Methods An animal model of OSAHS was developed from SD rats, and the elastic properties of the soft palate of the rat model were measured in vitro through uniaxial tensile experiments. Results To compare with the control one, the mechanical properties of the soft palate and the phenomenon of its remodeling related to OSAHS were discussed. Conclusion It was shown that pharyngeal respiratory pressure analogous to that of OSAHS episodes can cause the soft palate remodeling prone to OSAHS's formation and development.