Objective The purpose of this paper is to simulate the alterations of pressure-volume loop of left ventricle due to the changes of pre- and after-load and induced by cardiac valve diseases. Methods The simulations were performed by using Ursino model, which took into account the whole circulation system including heart, arterial and venous systems. The equations of flow across heart valves were modified in order to calculate the reverse flow in the condition of valves diseases. Results Firsly, the influences of pre-load, after-load of left ventricle and myocardial inotropism on ventricular pressure-volume loops were calculated. Based on these data, the pressure-volume loops with mitral obstruction, mitral inadequacy, aortic stenosis and both aortic stenosis and insufficiency were simulated. Conclusion The results showed that there are significant influences of heart valves disease on the left ventricle function. It also indicated that the clamped parameter model describing the whole cardiovascular system is an adequate tool to be applied to simulate not only vascular system, but also the heart function.