Objective The bond effect of the fluoride-releasing orthodontic adhesive was studied in vitro. Methods To test and compare the shear bond strength and the penetration depth of resin tags of fluoride-releasing orthodontic adhesives with those of the traditional orthodontic adhesive.Results There are no significant statistically differences between fluoride-releasing orthodontic adhesive and the control (nonfluoride) in shear bond strength and penetration depth of resin tags. Conclusion There are no significant statistically differences between fluoride-releasing orthodontic adhesive and the control (nonfluoride) in bond effect.