Purpose: To investigate the compliance change of femoral arteries and veins in rabbit with different axis stretch ratio, evaluated the particular reference to the option of vascular repair. Methods: A mechanical analysis including stress-strain experiment and axis stretch ratio measurement was undertaken to evaluated the compliance change of femoral arteries and veins in rabbit with different axis stretch ratio. Results: The compliance is related to the pressure and the axis stretch ratio. In the artery pressure, the section area decreased 40% with axis stretch ratio of 1.9 than axis stretch ratio of 1.58 of femoral artery in rabbit, the same as that of vein. Conclusion: When the pressure was 1.19g on anastomoses, the compliance of femoral arteries was equal to that of veins in atrerial pressure. And the inner diameter of femoral arteries decreased with the axis stretch ratio increasing. It suggested to repair the injuried vessel according to the biomechanical effect.