Objective To improve the efficiency and quality of end-to-end anastomosis, a novel degradable vascular anastomosis device was designed, and the relationship between pressure distance and biomechanical properties of the anastomotic stoma was explored. Methods A three-dimensional (3D) structure of The vascular anastomosis device was designed and a prototype was fabricated with extruded high-purity magnesium. A finite element model of the end-to-end vascular anastomosis was established to study the stress distributions of the anastomosis end face under different pressure distances (0.4, 0.5, 0.6, 0.7, and 0.8 mm) and their change rules. In vitro experiments were conducted to verify the rationality of the finite element results as well as the feasibility and effectiveness of the vascular anastomosis device. Results When the pressure distance was 0.6 mm, the anastomosis tensile force, and burst pressure could reach (11.79±0.64) N and (39.32±2.99) kPa, respectively, meeting the clinical requirement for the strength of vascular anastomosis, and with the minimal mechanical damages to tissues. Conclusions The device designed in this study can be used for vascular anastomosis by adjusting the pressure distance, and it can improve operation efficiency, reduce mechanical damage to tissues, and further improve the quality of anastomosis. These results provide an essential reference for the design of degradable vascular anastomosis devices.