Objective To investigate the influence of different cell structures on the static and dynamic mechanical performance of porous titanium alloy scaffolds, and to provide a theoretical mechanical basis for the application of scaffolds in the repair of mandibular bone defects. Methods Porous titanium alloy scaffolds with diamond, cubic, and cross-sectional cubic cell structures were manufactured using three-dimensional printing technology. Uniaxial compression tests and ratcheting fatigue with compression load tests were conducted to analyze the static and dynamic mechanical performances of scaffolds with different cell structures. Results The elastic moduli of the diamond cell, cross-sectional cubic cell, and cubic cell scaffolds were 1.17, 0.566, and 0.322 GPa, respectively, and the yield strengths were 71.8, 65.1, and 31.8 MPa, respectively. After reaching the stable stage, the ratcheting strains of the cross-sectional cubic, diamond, and cubic cell scaffolds were 3.3%, 4.0%, and 4.5%, respectively. The ratcheting strain increased with increasing average stress, stress amplitude, and peak holding time, and decreased with increasing loading rate. Conclusions The evaluation results of the static mechanical performance showed that the diamond cell scaffold was the best, followed by the cross-sectional cubic cell scaffold and the cubic cell scaffold. The evaluation results of the dynamic mechanical performance showed that the cross-sectional cubic cell scaffold performed the best, followed by the diamond cell scaffold, whereas the cubic cell scaffold performed the worst. The fatigue performance of the scaffold is affected by the loading conditions. These results provide new insights for scaffold construction for the repair of mandibular bone defects and provide an experimental basis for further clinical applications of this scaffold technology.