In the nasal cavity, nitric oxide (NO) is involved in many physiological functions, including antibacterial and antiviral activity, promotion of nasal mucociliary clearance, and regulation of blood vessel expansion in the nasal mucosa. The abnormal concentration of NO will lead to the occurrence of various nasal diseases, and NO concentration has become a biological indicator for routine clinical detection of airway inflammation. With the indepth intersection of medicine and mechanics and other fields, the use of numerical research methods, combined with traditional experimental methods, the distribution of NO concentration in nasal cavity can be analyzed, and NO concentration in various parts of nasal cavity can be quantified, so as to obtain the distribution patterns of NO in nasal cavity, assist the clinical diagnosis and treatment of related nasal diseases, and help promote the development of precision medicine. In this review, the progress of experimental and numerical studies on the distribution of NO concentration in nasal cavity was summarized, and the future research direction was prospected.