Objective To study the anti-migration mechanical behavior of balloon-expanded aortic valve stent afteimplantation. Methods The mechanical model of anti-migration of balloon-expanded valve stent after interventional treatment of aortic valve was established. The effects of different valve ring ellipticity, friction coefficient, valve stent material and calcification of autogenous valve leaflet on anti-migration of valve stent were studied by numerical simulation method. Results When the ellipticity of aortic valve ring was 0. 2, 0. 3, 0. 4 and 0. 5, the corresponding maximum anti-migration force was 12. 37, 10. 94, 8. 50 and 4. 75 N, respectively. When the friction coefficient was 0. 1, 0. 2 and 0. 3, the maximum anti-migration force of valve stent was 8. 98, 11. 00 and 13. 10 N, respectively. The anchoring performance of valve stent made of L605 cobalt-chromium alloy was better than that made of 316L stainless steel, and its corresponding maximum anti-migration force was 13. 10, 9. 82 N, respectively. When the autogenous valve was calcified, the maximum anti-migration force was 13. 1 N. When the autogenous valve was not calcified, the maximum anti-migration force was only 5. 51 N, decreased by 57. 9% . Conclusions With the increase in ellipticity of aortic valve ring, the anchoring of valve stent decreases gradually. As the friction coefficient between the valve stent and the tissue increases, the maximum anti-migration force also increases. The anchoring performance of valve stent made of L605 cobalt-chromium alloy is superior to that made of 316L stainless steel. The anchoring of valve stent with calcification is better than that without calcification. The results in this study provide an important scientific basis for structural design and clinical selection of anti-migration valve stent.